Super Physio Dr

   –Meningitis is the most frequent and serious infection of the CNS and affects the pia matter, arachnoids (leptomeninges) and subarachnoid space. – Early onset –Early onset infection with streptococcus Agalactiae generally presents at or within 24 hours of birth but can occur through day 6 of life. – Late onset Late onset has been variably defined for epidemiological purposes as occurring from 1 st week to 5 year age after birth. Late onset infections with Streptococcus Agalactiae usually occur within four to five weeks of age. –Despite advances in the early diagnosis and the treatment of new meningitis, it still causes high morbidity and frequent neurological sequelae in survivors. The development of meningitis is described in approx. 15% of new born diagnosed with bacteriaemia. Pre-term birth, low birth weight, pre-mature rupture of the membranes and maternal Peri-Partum infections are the major factors of neonatal meningitis and sepsis. – CAUSE –The leading causative bacte...

 VASCULITIS Vasculitis is inflammation of your blood vessels. It causes changes in the blood vessel walls, including thickening, weakening, narrowing or scarring. These changes can restrict blood flow, resulting in organ and tissue damage. Vasculitis might affect just one organ, or several. The condition can be short term (acute) or long lasting (chronic). Vasculitis is also known as angiitis and arteritis. TYPES OF VASCULITIS There are many types of vasculitis, and most of them are rare. Behcet’s disease Buerger’s disease Chrug Strauss syndrome Crygobulinemia Giant cell arteritis Granulomatosis with polyangitis Henoch scholein purpura Kawasaki disease Takayasu’s arteritis SYMPTOMS The signs and symptoms of vasculitis vary greatly. They're often related to decreased blood flow throughout the body GENERAL SIGNS AND SYMPTOMS General signs and symptoms of vasculitis include: Fever Headache Fatigue Weight loss General aches and pains Night s...

 

  Drugs Used to Control Gastric Acidity and Secretion The acidic nature of the gastric juices is essential for activating digestive protease activity and controlling intestinal bacteria. The gastric acids, however, can cause severe ulceration and hemorrhage of the stomach lining if excessive amounts of acid are produced or if the normal protection of the stomach mucosa is disturbed by irritants, drugs, or bacterial infection. Agents used to control gastric acidity and secretion are as follows; DETAILED MECHANISM OF ACTION OF PPI AND THERAPEUTIC USES MECHANISM OF ACTION The proton-pump inhibitors inhibit gastric acid by blocking the H+/K+-adenosine triphosphatase enzyme system (the proton pump) of the gastric parietal cell. PPIs undergo rapid first-pass and systemic hepatic metabolism and have negligible renal clearance PPIs are administered as inactive prodrugs. To protect the acid labile prodrug from rapid destruction within the gastric lumen, oral products are formulated for dela...

 BETA-2 AGONIST (salbutamol, salmeterol) Therapeutic effects Used to treat the symptoms of bronchospasm in asthma (both in an acute attack and as maintenance therapy) and chronic obstructive pulmonary disease (COPD). 1. relaxation of smooth muscle including bronchial, uterine and vascular  2. inhibition of release of inflammatory mediators  3. increased mucociliary clearance Adverse effects increase in heart rate, force of myocardial contraction speed of impulse conduction and enhanced production of ectopic foci in the myocardium and automaticity in pacemaker tissue. This can cause dysrhythmias and symptoms of palpitations. muscle tremor adverse metabolic effect hypokalemia (via redistribution of K into cells); raised free fatty acid concentrations; hyperglycemia due to a greater increase in glycogenolysis than in insulin secretion. desensitization MUSCARINIC RECEPTOR AGONIST (stramonium, ipratropine) Therapeutic effects ip...